Apolipoproteins and Serum Lipid Profile in Acute Myocardial Infarction

Acute Myocardial Infarction [AMI] is now a common disease with serious consequences in mortality and morbidity. Altered lipid profile with low HDL-C and high LDL-C and TGs has been implicated in coronary atherosclerosis. Recently it has been shown that measurement of Apoliopoproteins was superior to LDL-C and HDL-C in risk and prognosis of Acute Myocardial Infarction. We measured the Levels of Serum Lipids and Apoliporoteins Apo B100: Apo A-1 ratio in 32 Acute Myocardial Infarction patients and measured the values with age and sex matched controls. Statistical analysis was done using SPSS software version 17. p value less than 0.05 was considered significant. There was increase in serum LDL-C and TGs and Low HDL-C in patients with AMI. The ratio of Apo B100/Apo A-I (>1.0) was significantly related with Acute Myocardial Infarction. Within the limitations of the present study it can be concluded that levels of Total Cholesterol, LDL-C and TGs were elevated in Myocardial Infarction The ratio of ApoB100:apoA-I was significantly correlated with the AMI in individuals. Therefore ApoB100: Apo A-I ratio may be better in risk prediction and prognosis of AMI especially in younger age group.