Neurobiology of Disease Dopamine Modulates Release from Corticostriatal Terminals
نویسندگان
چکیده
Nigel S. Bamford,1,2,5 Siobhan Robinson,3 Richard D. Palmiter,3,4 John A. Joyce,1 Cynthia Moore,6 and Charles K. Meshul6 1Department of Neurology, 2Center on Human Development and Disability, 3Neurobiology and Behavior Program, and 4Howard Hughes Medical Institute, University of Washington, and 5Department of Pediatrics, Children’s Hospital and Regional Medical Center, Seattle, Washington 98195, and 6 Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239
منابع مشابه
Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Dopamine input to the striatum is required for voluntary motor movement, behavioral reinforcement, and responses to drugs of abuse. It is speculated that these functions are dependent on either excitatory or inhibitory modulation of corticostriatal synapses onto medium spiny neurons (MSNs). While dopamine modulates MSN excitability, a direct presynaptic effect on the corticostriatal input has n...
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