The Amelioration of Myelofibrosis with Thrombocytopenia by a JAK1/2 Inhibitor, Ruxolitinib, in a Post-polycythemia Vera Myelofibrosis Patient with a JAK2 Exon 12 Mutation

نویسندگان

  • Kazuhiko Ikeda
  • Koki Ueda
  • Takahiro Sano
  • Kazuei Ogawa
  • Takayuki Ikezoe
  • Yuko Hashimoto
  • Soji Morishita
  • Norio Komatsu
  • Hitoshi Ohto
  • Yasuchika Takeishi
چکیده

Less than 5% of patients with polycythemia vera (PV) show JAK2 exon 12 mutations. Although PV patients with JAK2 exon 12 mutations are known to develop post-PV myelofibrosis (MF) as well as PV with JAK2V617F, the role of JAK inhibitors in post-PV MF patients with JAK2 exon 12 mutations remains unknown. We describe how treatment with a JAK1/2 inhibitor, ruxolitinib, led to the rapid amelioration of marrow fibrosis, erythrocytosis and thrombocytopenia in a 77-year-old man with post-PV MF who carried a JAK2 exon 12 mutation (JAK2H538QK539L). This case suggests that ruxolitinib is a treatment option for post-PV MF in patients with thrombocytopenia or JAK2 exon 12 mutations.

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عنوان ژورنال:

دوره 56  شماره 

صفحات  -

تاریخ انتشار 2017