A clinically relevant method to screen for hepatic steatosis in overweight adolescents: a cross sectional study
نویسندگان
چکیده
BACKGROUND To develop a screening algorithm to detect hepatic steatosis in overweight and obese adolescents. METHODS We performed a cross sectional study of 129 overweight adolescents 13-18 yrs. The primary outcome, hepatic steatosis was defined as an intracellular triglyceride content > 5.5 mg/g and quantified using (1)H-magenetic resonance spectroscopy. Primary predictor variables included, alanine and aspartate transaminases (ALT/AST) and features of the metabolic syndrome. RESULTS Hepatic steatosis was present in 33% of overweight and obese adolescents. Adolescents with hepatic steatosis were more likely to be boys (adjusted OR: 4.8; 95% CI: 2.5-10.5), display a higher waist circumference (111 ± 12 vs 100 ± 13 cm, p < 0.001) and have metabolic syndrome (adjusted OR: 5.1; 95% CI: 1.6-16.4). Serum ALT predicted hepatic steatosis in boys (AUC: 0.82; 95% CI: 0.70-0.95; p < 0.001) but not girls (AUC = 0.63; 95% CI: 0.46-0.75, p = 0.16). An ALT >20 U/L, combined with the presence of metabolic syndrome, male gender and an elevated waist circumference provided the best model (AUC 0.85) with high sensitivity (72%) and specificity (82%) and positive and negative predictive values of 61% and 89% respectively. CONCLUSIONS Serum transaminases provide modest predictive value for hepatic steatosis in youth. The ALT threshold for predicting hepatic steatosis is significantly lower than current clinical thresholds for predicting non-alcoholic fatty liver disease. The addition of ALT, presence of the metabolic syndrome and male gender significant improve the ability to predict hepatic steatosis.
منابع مشابه
Metabolic Consequences of Hepatic Steatosis in Overweight and Obese Adolescents
OBJECTIVE To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with hepatic steatosis, 68 overweight and obese adolescents without hepatic steato...
متن کاملDietary determinants of hepatic steatosis and visceral adiposity in overweight and obese youth at risk of type 2 diabetes.
BACKGROUND Dietary determinants of hepatic steatosis, an important precursor for nonalcoholic fatty liver disease, are undefined. OBJECTIVE We explored the roles of sugar and fat intake as determinants of hepatic steatosis and visceral obesity in overweight adolescents at risk of type 2 diabetes. DESIGN This was a cross-sectional study of dietary patterns and adipose tissue distribution in ...
متن کاملEstimating Steatosis Prevalence in Overweight and Obese Children: Comparison of Bayesian Small Area and Direct Methods
Background Often, there is no access to sufficient sample size to estimate the prevalence using the method of direct estimator in all areas. The aim of this study was to compare small area’s Bayesian method and direct method in estimating the prevalence of steatosis in obese and overweight children. Materials and Methods: In this cross-sectional study, was conducted on 150 overweight and obese ...
متن کاملThe Prevalence of Weight Disorders in Children and Adolescents in Lorestan Province: Comparison of Three Different Criteria in A Cross-sectional Study
Background: Anthropometric studies in children and adolescents are important to screen changes in growth and puberty. Hence, standard percentiles and cutoffs are set by the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), and Iranian national criteria. This study aimed to examine and compare the prevalence of weight disorders in children and adolescents in Lore...
متن کاملموانع و حمایتهای انجام فعالیت فیزیکی در نوجوانان چاق و دارای اضافه وزن
Introduction and Aim: As the prevalence of overweight increases among adolescents, thus factors that may influence children’s participation in weight-related health behaviors need to be examied. This study examined barriers to and support for physical activity in overweight and obese adolescents compared with normal weight adolescents. Materials and Methods: In this cross-sectional study, samp...
متن کامل