Re 1 Postconditioning in hyperlipidemia 1 CHOLESTEROL DIET - INDUCED HYPERLIPIDEMIA IMPAIRS THE 1 CARDIOPROTECTIVE EFFECT OF POSTCONDITIONING : ROLE OF 2 PEROXYNITRITE 3 4

1 CHOLESTEROL DIET-INDUCED HYPERLIPIDEMIA IMPAIRS THE 1 CARDIOPROTECTIVE EFFECT OF POSTCONDITIONING: ROLE OF 2 PEROXYNITRITE 3 4 Krisztina Kupai*, Csaba Csonka*, Veronika Fekete, Louise Odendaal, 5 Jacques van Rooyen, De Wet Marais, Tamás Csont, Péter Ferdinandy 6 Cardiovascular Research Group, Department of Biochemistry, University of 7 Szeged, and PharmahungaryTM Group, Szeged, Hungary; Experimental Anti8 Oxidant Research Group, Faculty of Health and Wellness Sciences, Cape 9 Peninsula University of Technology, Cape Town, South Africa; Nutritional 10 Intervention Research Unit, Medical Research Council, South Africa 11 12 Running title: Postconditioning in hyperlipidemia: role of peroxynitrite 13 14 Word count: 4644 15 Address for correspondence: 16 Péter Ferdinandy, MD, PhD, MBA, 17 Cardiovascular Research Group, 18 Department of Biochemistry, University of Szeged 19 Dóm tér 9, Szeged, H-6720, Hungary 20 Tel: +36 62 545096, fax: +36 62 545097 21 E-mail: [email protected] 22 http://www.cardiovasc.com 23 24 * the authors have equally contributed to the present manuscript 25 26 Articles in PresS. Am J Physiol Heart Circ Physiol (September 4, 2009). doi:10.1152/ajpheart.00484.2009