Urocortin: a protective peptide that targets both the myocardium and vasculature.

Cell Protective Effect of Stress- Regulatory Peptide Urocortin in the Endogenous Adaptation Mechanisms of Myocardium

CELL PROTECTIVE EFFECT OF STRESS-REGULATORY PEPTIDE UROCORTIN IN THE ENDOGENOUS ADAPTATION MECHANISMS OF MYOCARDIUM PhD Thesis By

s/Idézhető absztraktok: 1. Jancsó G., Borsiczky B., Szántó Z., Cserepes B., Karosi Z., Solymos A., Kiss K., Szeberényi J., Rőth E. :NFkB és AP-1 transzkripciós faktorok indukciójának dinamikája a prekondicionált miokardiumban Cardiologia Hungarica 2002. 32; 3. 193. 2. Jancsó G, Borsiczky B, Szántó Z, Cserepes B, Gasz B, Karosi Z, Solymos A, Kiss K, Szeberényi J, Rőth E. Nukleáris Faktor-kB és A...

Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway.

Reperfusion of ischemic myocardium is essential for tissue salvage but paradoxically contributes to cell death. We hypothesized that activation of potential survival pathways such as p42/p44 MAPK may prevent lethal reperfusion injury. Urocortin is a peptide factor that affects the p42/p44 MAPK signaling pathway. Both isolated and in vivo rat heart models were used to examine the potential for u...

Exploring new drugs for heart failure: the case of urocortin.

Over the past decade, clinical development of natriuretic peptide analogues as drug therapy for acute heart failure has sparked a wide range of interests to seek other endogenous vasoactive peptide systems that are operative as adaptive responders in human heart failure. With rapid advances in the molecular understanding of heart failure pathogenesis, several novel neurohormonal systems have be...

Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I.

Urocortin and urocortin II are members of the corticotropin-releasing hormone (CRH) family of neuropeptides that function to regulate stress responses. Two high-affinity G-protein-coupled receptors have been identified that bind CRH and/or urocortin I and II, designated CRHR1 and CRHR2, both of which are present in hippocampal regions of mammalian brain. The hippocampus plays an important role ...