Representation of Odorants by Receptor Neuron Input to the Mouse Olfactory Bulb

Interglomerular center-surround inhibition shapes odorant-evoked input to the mouse olfactory bulb in vivo.

Mouse olfactory receptor proteins have relatively broad odorant tuning profiles, so single odorants typically activate a substantial subset of glomeruli in the main olfactory bulb, resulting in stereotyped odorant- and concentration-dependent glomerular input maps. One of the functions of the olfactory bulb may be to reduce the extent of this rather widespread activation before transmitting the...

Selective imaging of the receptor neuron population in the olfactory bulb of zebrafish and mice.

The neuronal processing of odors takes place in several types of neurons, including the sensory neurons, projection neurons and interneurons. To understand the neuronal representation of odors and eventually the encoding of those odors it is important to selectively measure the contributions of the different neuron populations to odor-induced neuronal activity. We are analyzing the odor respons...

Matt Wachowiak and Lawrence B . Cohen the Mouse Olfactory Bulb Receptor Neuron Input and Intrinsic Optical Signals in Correspondence Between Odorant - Evoked Patterns of

Distributed and concentration-invariant spatial representations of odorants by receptor neuron input to the turtle olfactory bulb.

We sought to characterize how odorants are represented at the level of afferent input to the olfactory bulb of the box turtle, a terrestrial reptile that, like mammals, detects airborne odorants. Using methods developed first in zebrafish, we selectively labeled olfactory receptor neurons with Calcium Green-1 dextran and imaged odorant-evoked input to glomeruli in vivo. Odorant representations ...

Grouping of odorant receptors: odour maps in the mammalian olfactory bulb.

The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is converted into that at the cellular level (olfactory sensory neurons) by the one sen...