Building a Temperature-Sensitive Ion Channel
نویسندگان
چکیده
The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.
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ورودعنوان ژورنال:
- Cell
دوره 158 شماره
صفحات -
تاریخ انتشار 2014