Bone marrow hypoplasia, isochromosome 8q and deletion of chromosome 6q preceding B-cell lymphoma

نویسندگان

  • Nae Yu
  • Yoonjung Kim
  • Sung-eun Choi
  • Juwon Kim
  • Yu Ri Kim
  • Jong Rak Choi
  • Kyung-A Lee
چکیده

sis of the CSF showed neoplastic cells with a frequency of 92.0% (Fig. 2C) and positivity for both CD56 and CD123 on immunocytochemical staining (Fig. 2D). He was diagnosed with leptomeningeal involvement of BPDCN. He was treated with intrathecal injections of high-dose cytarabine (40 mg) and methotrexate (15 mg) for 3 months, and he has been in complete remission for 4 months without evidence of residual disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

T-cell large granular lymphocytic leukemia: 4 cases

Do cy-togenetic abnormalities precede morphologic abnormalities in a developing malignant condition? Eur J Haematol 2007;78: 152-6. 4. Wong KF, Kwong YL. Isochromosome 8q is a marker of secondary acute myeloid leukemia. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis. et al. 6q deletion detected by fluorescence in situ hybridization using bacterial artificia...

متن کامل

Localization by chromosome microdissection of a recurrent breakpoint region on chromosome 6 in human B-cell lymphoma.

Deletion of the long arm of chromosome 6 (6q) is one of the most common chromosomal alterations in human B-cell lymphomas. Conventional cytogenetic banding analysis and loss-of-heterozygosity (LOH) studies have detected several common regions of deletion ranging across the entire long arm (6q), with no defined recurrent breakpoint yet identified. We describe here a strategy combining chromosome...

متن کامل

Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6.

This report concerns a woman who experienced a relapse of acute lymphoblastic leukemia (ALL) associated with an interstitial deletion of the long arm of chromosome 6 in donor cells more than 4 years after allogeneic bone marrow transplantation (BMT). Direct bone marrow preparations revealed the presence of two leukemic clones 46,XY,del(6)(q23q25) and 45,X,-4,del(6)(q23q25),+8,-15,-21,+i(21q), +...

متن کامل

Intravascular large B-cell lymphoma manifesting as cholecystitis: report of an Asian variant showing gain of chromosome 18 with concurrent deletion of chromosome 6q.

Intravascular large B-cell lymphoma (IVLBCL), which involves the lumen of small vessels, is a rare variant of extranodal diffuse large B-cell lymphomas. Herein, we present a case of IVLBCL manifesting as cholecystitis in a 77-year-old Japanese man. He presented with fever, fatigue, and weight loss. Physical examination revealed tenderness of the right upper quadrant. The white blood cell count ...

متن کامل

Primary acquired red cell hypoplasia associated with a clonal chromosomal abnormality and disturbed erythroid proliferation.

characterized by deletion of most of the long arm of a B group chromosome (Bq-). Chromosomes of blood lymphocytes and skin fibroblasts were normal. “Fe labeling of bone marrow metaphases demonstrated the abnormal chromosome in developing erythroid cells, and it was considered to be present in the common erythroid-myeloid precursor stem cell and its derivatives. Studies of bone marrow cell proli...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 49  شماره 

صفحات  -

تاریخ انتشار 2014