Murine and Human Autotaxin , , and Isoforms
نویسندگان
چکیده
Adeline Giganti, Marianne Rodriguez, Benjamin Fould, Natacha Moulharat, Francis Cogé, Pascale Chomarat, Jean-Pierre Galizzi, Philippe Valet, Jean-Sébastien Saulnier-Blache, Jean A. Boutin, and Gilles Ferry From Pharmacologie Moléculaire et Cellulaire and Pharmacologie et Physiopathologie Moléculaire, Institut de Recherches Servier, 78290 Croissy-sur-Seine and INSERM U858/I2MR, Department of Metabolism and Obesity, Team 3, 1 Avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France
منابع مشابه
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). LPA is a phospholipid possessing a large panel of activity, in particular as a motility factor or as a growth signal, through its G-protein coupled seven transmembrane receptors. Indirect evidence strongly suggests that autotaxin is the main, if not the only source of circulating LPA. Because of ...
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The production of murine monoclonal antibody (MAb) has not yet been reported in Iran. The present work describes for the first time the generation of several murine hybridoma clones secreting MAbs directed against human leukocyte surface antigens. The secreted antibodies by hybridoma clones have been screened on different lymphoid and non-lymphoid tissues. Results indicated that of seven h...
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a key factor in spermatogenesis and disorders associated with this protein have been recognized to be related to male infertility. Although it was suggested that this protein could have different functions during germ cell development, no studies have been conducted to uncover the mechanism of this potential function yet. Here, we analyzed the expression pattern of RBMY protein isoforms in test...
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Background Asthenozoospermia accounts for almost 50% of the cases of male infertility. Our study investigating phosphoproteins differentially expressed in asthenozoosperm has identified the phosphoproteins relevant to sperm motility and the signature molecules likely to be altered in asthenozoospermia. The 66 phosphoproteins differentially expressed included four alpha tubulin isoforms which we...
متن کاملCyclic phosphatidic acid is produced by autotaxin in blood.
Cyclic phosphatidic acid (cPA), an analog of lysophosphatidic acid (LPA), was previously identified in human serum. Although cPA possesses distinct physiological activities not elicited by LPA, its biochemical origins have scarcely been studied. In the present study, we assayed cPA formation from lysophosphatidylcholine in fetal bovine serum and found significant activity of transphosphatidylat...
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