Corrigendum to “Maternal pak4 expression is required for primitive myelopoiesis in zebrafish” [Mech. Dev. 130 (2013) 181–194]

نویسندگان

  • Sheran H.W. Law
  • Thomas D. Sargent
چکیده

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Maternal pak4 expression is required for primitive myelopoiesis in zebrafish

Transcripts of pak4, the zebrafish ortholog of p21-activated kinase 4 (PAK4), are most abundant in the egg and fall to low levels by the end of gastrulation, after which expression is essentially ubiquitous. Translation of maternal mRNA into pak4 protein is first detectable at high stage (3.3hpf). Splice-blocking morpholino oligonucleotides (MOs) were used to prevent zygotic pak4 expression. Th...

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Corrigendum to “The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development” [Mech. Dev. 117 (2002) 305–309]

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Retinoic Acid Signaling Plays a Restrictive Role in Zebrafish Primitive Myelopoiesis

Retinoic acid (RA) is known to regulate definitive myelopoiesis but its role in vertebrate primitive myelopoiesis remains unclear. Here we report that zebrafish primitive myelopoiesis is restricted by RA in a dose dependent manner mainly before 11 hpf (hours post fertilization) when anterior hemangioblasts are initiated to form. RA treatment significantly reduces expressions of anterior hemangi...

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Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.

The zebrafish has become a powerful tool for analysis of vertebrate hematopoiesis. Zebrafish, unlike mammals, have a robust primitive myeloid pathway that generates both granulocytes and macrophages. It is not clear how this unique primitive myeloid pathway relates to mammalian definitive hematopoiesis. In this study, we show that the two myeloid subsets can be distinguished using RNA in situ h...

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عنوان ژورنال:
  • Mechanisms of Development

دوره 130  شماره 

صفحات  -

تاریخ انتشار 2013