Making the T - type even tinier – CRF mediated inhibition of low voltage activated calcium channel activity

T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental, however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in comparison with other voltage-dependent calcium channels. In this issue of Molecular Pharmacology, Tao and colleagues demonstrate that Cav3.2 is regulated by activation of the corticotroprin-releasing factor receptor 1 in a Gβγ-dependent manner. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on March 7, 2008 as DOI: 10.1124/mol.108.046961 at A PE T Jornals on Sptem er 4, 2016 m oharm .aspeurnals.org D ow nladed from