Herpes simplex virus gE / gI extracellular domains promote axonal transport 8 and spread from neurons to epithelial cells
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چکیده
1 2 3 4 5 6 7 Herpes simplex virus gE/gI extracellular domains promote axonal transport 8 and spread from neurons to epithelial cells. 9 10 Paul W. Howard, Catherine C. Wright, Tiffani Howard and David C. Johnson* 11 12 Department of Molecular Microbiology & Immunology 13 Oregon Health & Science University 14 Portland, OR 97239 15 16 Running title: HSV gE/gI promotes neuron-to-epithelial cell spread. 17 * Corresponding author: 18 Mail code L-220, Dept. of Microbiology & Immunology, 19 Oregon Health & Sciences University, 20 3181 SW Sam Jackson Park Rd. 21 Portland, OR 97239 22 [email protected] 23 503 494 2432 (assistant) 24 503 494 0835 (lab) 25 JVI Accepts, published online ahead of print on 16 July 2014 J. Virol. doi:10.1128/JVI.01627-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells.
UNLABELLED Following reactivation from latency, there are two distinct steps in the spread of herpes simplex virus (HSV) from infected neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies to axon tips and (ii) exocytosis and spread of extracellular virions across cell junctions into adjacent epithelial cells. The HSV heterodimeric glycoprotein gE/g...
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Herpes simplex virus (HSV) and other alphaherpesviruses must move from sites of latency in ganglia to peripheral epithelial cells. How HSV navigates in neuronal axons is not well understood. Two HSV membrane proteins, gE/gI and US9, are key to understanding the processes by which viral glycoproteins, unenveloped capsids, and enveloped virions are transported toward axon tips. Whether gE/gI and ...
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