Omega-3 fatty acids, zinc and probiotics supplements in cystic fibrosis

In humans, the polyunsaturated fatty acids (PUFA) linoleic acid (18:2 omega-6, or n-6) and alpha-linolenic (18:3 omega-3, or n3) are ’essential’ for normal growth and function; the only source is dietary. Research into the omega-3 series of essential polyunsaturated fatty acids stems from the observation that the native Inuit (Eskimo) of Greenland (who consume a traditional diet rich in fish oils) have a very low incidence of some of the chronic inflammatory immune-based disorders commonly found in Europe and North America. Omega-3 fatty acids have been shown to play an important role in the integrity of cellular membranes, where they exert anti-inflammatory response. Essential fatty acid deficiency may contribute to the development of respiratory disease in infants with CF, even before clinical signs become apparent.