Severe Hyperparathyroidism with Secondary Osteitis Fibrosa Cystica and Brown Tumors Mimicking Bone Metastasis
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چکیده
Introduction: The classical presentation of primary hyperparathyroidism, osteitis fibrosa cystica, has become very rare nowadays. This rarity makes it sometimes misdiagnosed leading to disastrous outcomes. Methods: We present a case of an undiagnosed primary hyperparathyroidism with severe osteitis fibrosa cystica and brown tumors that was first misdiagnosed as having bone metastasis. Conclusion: Osteitis fibrosa cystica although rare should be considered in the differential diagnosis of patients presenting with multiple brown tumors, especially since the diagnosis can be easily made by a simple calcium level, thereby avoiding severe adverse outcomes.
منابع مشابه
Multilevel brown tumors of the spine in a patient with severe secondary hyperparathyroidism A case report and review of the literature.
BACKGROUND The brown tumour is an extreme form of osteitis fibrosa cystica, representing a serious complication of the advanced primary or secondary hyperparathyroidism. It occurs in settings of high levels parathyroid hormone, like in primary or secondary hyperparathyroidism, with a frequency of 3-4% and 1.5-13% respectively, usually affecting young people. CASE REPORT The authors report a c...
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BACKGROUND Primary hyperparathyroidism is an endocrinopathic condition characterized by hypersecretion of parathyroid hormone. Excess parathyroid hormone results in an altered state of osseous metabolism involving bone resorption and tissue change known as osteitis fibrosa cystica, which is the end stage of primary hyperparathyroidism. Osteitis fibrosa cystica is associated with the development...
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BACKGROUND Long-term severe hyperparathyroidism leads to thinning of cortical bone and cystic bone defects referred to as osteitis fibrosa cystica. Cysts filled with hemosiderin deposits may appear colored as "brown tumors." Osteitis fibrosa cystica and brown tumors are occasionally visualized as multiple, potentially corticalis-disrupting bone lesions mimicking metastases by bone scintigraphy ...
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The most common clinical presentation of primary hyperparathyroidism (PHP) is asymptomatic hypercalcemia, and diagnosis of PHP based on the presence of bone manifestations such as osteitis fibrosa cystica (OFC) is increasingly uncommon. OFC occurs in less than 5% of patients with PHP and suggests a more severe or long-standing disease. OFC is characterized by the occurrence of bone pain associa...
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Parathyroid glands produce parathyroid hormone (PTH). PTH has a main role in bone formation. Hyperparathyroidism (HPT) is explained as primary, secondary and tertiary types defined as overproduction of PTH. The brown tumor or osteitis fibrosa cystica is a benign bone lesion that is caused by HPT. This complication has been decreased by diagnosis and successful treatment of secondary hyperparath...
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