A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles
نویسندگان
چکیده
We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
منابع مشابه
Correction: A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles
In the Funding section, the grant number from the funder Austrian Science Fund (FWF) is missing. The grant number is: T 478-N13. The publisher apologizes for the error. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملتاثیر دما بر کاهش قدرت عضلانی ایزومتریک متعاقب تمرینات اکسنتریک در عضله گاستروکنمیوس داخلی ایزوله پرفیوز شده موش صحرائی
Background: The typical features of eccentric exercise-induced muscle damage are delayed-onset muscle soreness (DOMS) and prolonged loss of muscle strength. It has been shown that passive warmth is effective in reducing muscle injury. Due to the interaction of different systems in vivo, we used isolated perfused medial gastrocnemius skeletal muscle to study the direct effect of temperature on t...
متن کاملThe Changes of Leg Musclus Activities Following Increase of Gait Velocity
Purpose: Motor control evaluation and analysis of it"s specifications for diagnosis of neuromuscular diseases is new approach in clinical electroneurophysiology, that is based on the changes of electromyography responses and classic reflexes in this field. In this study quantitative power spectrum frequency used for changes of motor control strategies. Materials and Methods: Twenty five health...
متن کاملThe role of titin in eccentric muscle contraction.
Muscle contraction and force regulation in skeletal muscle have been thought to occur exclusively through the relative sliding of and the interaction between the contractile filaments actin and myosin. While this two-filament sarcomere model has worked well in explaining the properties of isometrically and concentrically contracting muscle, it has failed miserably in explaining experimental obs...
متن کاملEffects of Concentric and Eccentric Strength Training on Electromyography Activity of the Knee Agonist –Antagonist Muscle
Purpose: An appropriate activity of the knee agonist -antagonist muscles is important to resist against abnormal abduction-adduction moments loads around knee joint and reduce the risk of knee injuries. Exercise training has been commonly used as an intervention to improve neuromuscular activity within the synergic and/or agonist-antagonist muscles. However, maximizing the effectiveness of exer...
متن کامل