EPs 7630 in Acute Respiratory Tract Infections –Asystematic Review and Meta-Analysis of Randomized Clinical Trials
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چکیده
Submit Manuscript | http://medcraveonline.com Abbreviations: AB: Acute Bronchitis; AE: Adverse Event; ARS: Acute Rhinosinusitis; ATP: Acute Tonsillopharyngitis; BSS: Bronchitis Severity Scale; CI: Confidence Interval; IMOS: Integrative Medicine Outcome Scale; ISRCTN: International Standard Randomized Controlled Trial Number; MEDLINE: Medical Literature Analysis and Retrieval System Online; RTI: Respiratory Tract Infection; SSS: Sinusitis Severity Score; TSS: Tonsillitis Severity Score
منابع مشابه
Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children
Background In numerous randomized controlled trials (RCTs) and systematic reviews such as those published by the Cochrane Collaboration, Pelargonium sidoides extract EPs® 7630 was shown to be effective in acute respiratory tract infections (aRTI) in all investigated age-groups. This narrative review focuses on recently published results from RCTs investigating the clinical efficacy and safety o...
متن کاملEfficacy and tolerability of EPs 7630 in patients (aged 6–18 years old) with acute bronchitis
AIM For EPs-7630, a herbal drug preparation from Pelargonium sidoides roots, therapeutic effects in respiratory tract infections outside the strict indication for antibiotics have already been demonstrated in adults. Now, a dose-finding study for EPs-7630 was performed in children and adolescents. METHODS A total of 400 patients (aged 6-18 years) were randomized to receive either 30 mg, 60 mg...
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EPs® 7630 is an aqueous-ethanolic extract of the roots of Pelargonium sidoides, employed in the treatment of upper respiratory tract infections. Its anti-infective activity is supposed to be associated with the activation of the nonspecific immune system. Using Leishmania major GFP-infected murine BMMΦ, the NO production of EPs® 7630-activated macrophages was correlated with the reduction of th...
متن کاملEPs 7630, a Herbal Drug Preparation for Treating Acute Bronchitis in Children and Adults
Herbal medicines play an increasingly important role in the perception of physicians and patients looking for equally effective, albeit safer approaches to conventional management of acute bronchitis. A no antibiotic or delayed antibiotic prescribing strategy to reduce the inappropriate prescribing of antibiotics for respiratory tract infections (RTI) has been advocated since the late 1990’s (L...
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Pelargonium sidoides is a medical herb and respective extracts are used very frequently for the treatment of respiratory tract infections. However, the effects of Pelargonium sidoides and a special extract prepared from its roots (EPs 7630) on human immune cells are not fully understood. Here we demonstrate that EPs 7630 induced a rapid and dose-dependent production of TNF-α, IL-6, and IL-10 by...
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