Regulation and evolutionary origins of repulsive guidance molecule C / hemojuvelin expression : a muscle-enriched gene involved in iron metabolism
نویسندگان
چکیده
s: M.G. West, M. Hwang, S. Kadkhodayan, C. Severyn, M.P. Thelen (November 1999).Overexpression in hamster cells of hXRCC1 containing a debilitating mutation in thePARP-binding BRCT domain. American Society for Microbiology (ASM), DNA Repairand Mutagenesis Conference, Hilton Head, SC. UCRL-JC-135806 Abs C. Severyn and P. Rotwein (May 2008) Characterizing RGMc/Hemojuvelin GeneExpression through Functional Studies and Evolutionary Conservation. IntegratingEvolution, Development, and Genomics (IEDG) Conference, Berkeley, CA. C. Severyn and P. Rotwein (April 2010) Conserved elements regulateRGMc/Hemojuvelin promoter activity in skeletal muscle. Keystone Symposium onDynamics of Eukaryotic Transcription during Development, Big Sky, MT. C. Severyn and P. Rotwein (May 2010) Characterizing RGMc/hemojuvelin expression: amuscle-enriched gene involved in systemic iron metabolism. NHLBI Physician ScientistTrainees Conference, Bethesda, MD.
منابع مشابه
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.
Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels o...
متن کاملComplex biosynthesis of the muscle-enriched iron regulator RGMc.
The recently discovered repulsive guidance molecule c (RGMc or hemojuvelin) gene encodes a putative glycosylphosphatidylinositol (GPI)-anchored protein that is expressed in striated muscle and in liver. Mutations in this gene have been linked to the severe iron storage disease, juvenile hemochromatosis, although the mechanisms of action of RGMc in iron metabolism are unknown. As a first step to...
متن کاملRED CELLS Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels o...
متن کاملImmunoassay for human serum hemojuvelin.
BACKGROUND Hemojuvelin, a critical regulator of iron homeostasis, is involved in the regulation of hepcidin expression and iron homeostasis. It is expressed both as a membrane-bound form and as a soluble one. Serum hemojuvelin can be produced by secretion following furin cleavage or by proteolytic cleavage of the membrane-bound form by matriptase 2 (TMPRSS6). These forms contribute to down-regu...
متن کاملDragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.
Repulsive guidance molecule (RGM) family members RGMa, RGMb/Dragon, and RGMc/hemojuvelin were found recently to act as bone morphogenetic protein (BMP) coreceptors that enhance BMP signaling activity. Although our previous studies have shown that hemojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the BMP signaling mediated by Dragon remains largel...
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