PML, SUMO, and RNF4: guardians of nuclear protein quality.
نویسندگان
چکیده
In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.
منابع مشابه
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ورودعنوان ژورنال:
- Molecular cell
دوره 55 1 شماره
صفحات -
تاریخ انتشار 2014