Molecular Darwinian evolution of virulence in Yersinia pestis.
نویسندگان
چکیده
1 2 3 4 5 6 Molecular Darwinian evolution of virulence in Yersinia pestis 7 8 9 10 Dongsheng Zhou, and Ruifu Yang 11 12 State Key Laboratory of Pathogen and Biosecurity, 13 Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China 14 15 16 17 Correspondence: 18 Dongsheng Zhou, Associate Professor, Ph.D. 19 E-mail: [email protected] 20 Tel: 086-10-66948594 21 22 Ruifu Yang, Professor, Ph.D. 23 E-mail: [email protected] 24 Tel: 086-10-66948595 25 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.01477-08 IAI Accepts, published online ahead of print on 16 March 2009
منابع مشابه
The evolution of flea-borne transmission in Yersinia pestis.
Transmission by fleabite is a recent evolutionary adaptation that distinguishes Yersinia pestis, the agent of plague, from Yersinia pseudotuberculosis and all other enteric bacteria. The very close genetic relationship between Y. pestis and Y. pseudotuberculosis indicates that just a few discrete genetic changes were sufficient to give rise to flea-borne transmission. Y. pestis exhibits a disti...
متن کاملYersinia pestis and Yersinia pseudotuberculosis infection: a regulatory RNA perspective
Yersinia pestis, responsible for causing fulminant plague, has evolved clonally from the enteric pathogen, Y. pseudotuberculosis, which in contrast, causes a relatively benign enteric illness. An ~97% nucleotide identity over 75% of their shared protein coding genes is maintained between these two pathogens, leaving much conjecture regarding the molecular determinants responsible for producing ...
متن کاملEvolution and virulence contributions of the autotransporter proteins YapJ and YapK of Yersinia pestis CO92 and their homologs in Y. pseudotuberculosis IP32953.
Yersinia pestis, the causative agent of plague, evolved from the gastrointestinal pathogen Yersinia pseudotuberculosis. Both species have numerous type Va autotransporters, most of which appear to be highly conserved. In Y. pestis CO92, the autotransporter genes yapK and yapJ share a high level of sequence identity. By comparing yapK and yapJ to three homologous genes in Y. pseudotuberculosis I...
متن کاملDefective Innate Cell Response and Lymph Node Infiltration Specify Yersinia pestis Infection
Since its recent emergence from the enteropathogen Yersinia pseudotuberculosis, Y. pestis, the plague agent, has acquired an intradermal (id) route of entry and an extreme virulence. To identify pathophysiological events associated with the Y. pestis high degree of pathogenicity, we compared disease progression and evolution in mice after id inoculation of the two Yersinia species. Mortality st...
متن کاملMolecular Characterization of Transcriptional Regulation of rovA by PhoP and RovA in Yersinia pestis
BACKGROUND Yersinia pestis is the causative agent of plague. The two transcriptional regulators, PhoP and RovA, are required for the virulence of Y. pestis through the regulation of various virulence-associated loci. They are the global regulators controlling two distinct large complexes of cellular pathways. METHODOLOGY/PRINCIPAL FINDINGS Based on the LacZ fusion, primer extension, gel mobil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Infection and immunity
دوره 77 6 شماره
صفحات -
تاریخ انتشار 2009