Caring Ambassadors Program Hepatitis C Literature Review
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Diabetes Mellitus is Associated With Higher Risk of Developing Decompensated Cirrhosis in Chronic Hepatitis C Patients. Saeed MJ1, Olsen MA, Powderly WG, Presti RM. J Clin Gastroenterol. 2017 Jan;51(1):70-76. GOALS: To investigate the association of diabetes with risk of decompensated cirrhosis in patients with chronic hepatitis C (CHC). BACKGROUND: Direct-acting antivirals are highly effective in treating CHC but very expensive. CHC patients at high risk of progression to symptomatic liver disease may benefit most from early treatment. STUDY: We conducted a retrospective cohort study using the 2006 to 2013 Truven Health Analytics MarketScan Commercial Claims and Encounters database including inpatient, outpatient, and pharmacy claims from private insurers. CHC and cirrhosis were identified using ICD-9-CM diagnosis codes; baseline diabetes was identified by diagnosis codes or antidiabetic medications. CHC patients were followed to identify decompensated cirrhosis. Multivariable Cox proportional hazards regression was used to model the risk of decompensated cirrhosis by baseline cirrhosis. RESULTS: There were 75,805 CHC patients with median 1.9 years follow-up. A total of 10,317 (13.6%) of the CHC population had diabetes. The rates of decompensated cirrhosis per 1000 person-years were: 185.5 for persons with baseline cirrhosis and diabetes, 119.8 for persons with cirrhosis and no diabetes, 35.3 for persons with no cirrhosis and diabetes, and 17.1 for persons with no cirrhosis and no diabetes. Diabetes was associated with increased risk of decompensated cirrhosis in persons with baseline cirrhosis (adjusted hazard ratio=1.4; 95% confidence interval, 1.3-1.6) and in persons without baseline cirrhosis (adjusted hazard ratio=1.9; 95% confidence interval, 1.7-2.1). CONCLUSIONS: In a privately insured US population with CHC, the adjusted risk of decompensated cirrhosis was higher in diabetic compared with nondiabetic patients. Diabetes status should be included in prioritization of antiviral treatment.
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Caring Ambassadors Program Hepatitis C Literature Review © 2016 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
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متن کاملCaring Ambassadors Program Hepatitis C Literature Review © 2015 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
متن کامل
Caring Ambassadors Program Hepatitis C Literature Review © 2015 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
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Caring Ambassadors Program Hepatitis C Literature Review © 2018 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
Successful retreatment with sofosbuvir plus ledipasvir for cirrhotic patients with hepatitis C virus genotype 1b, who discontinued the prior treatment with asunaprevir plus daclatasvir: A case series and review of the literature. Haga Y1, Kanda T1,2, Yasui S1, et al. Oncotarget. 2017 Dec 29;9(4):5509-5513. doi: 10.18632/oncotarget.23768. eCollection 2018 Jan 12. BACKGROUND: Interferon-free trea...
متن کاملCaring Ambassadors Program Hepatitis C Literature Review © 2013 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
High proportion of hepatitis C virus in community Asian American patients with nonliver-related complaints. Kin KC, Lin B, Ha NB, et al. J Clin Gastroenterol. 2013 Apr;47(4):367-71. doi: 10.1097/MCG.0b013e3182688b3e. http://www.ncbi.nlm.nih.gov/pubmed/23090039 GOALS AND BACKGROUND: Besides United States population born between 1945 and 1965, screening for hepatitis C virus (HCV) is not recommen...
متن کاملCaring Ambassadors Program Hepatitis C Literature Review © 2017 Caring Ambassadors Program Hepatitis C Newsletter www.HepCChallenge.org
Results of sofosbuvir-based combination therapy for chronic hepatitis C cohort of Indian patients in real-life clinical practice. Sood A1, Midha V2, Mahajan R1, et al. J Gastroenterol Hepatol. 2017 Apr;32(4):894-900. doi: 10.1111/jgh.13628. BACKGROUND AND AIM: The introduction of sofosbuvir has revolutionized the treatment of chronic hepatitis C. This study was planned to observe whether the ef...
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