Menopausal Hormone Therapy and New-onset Diabetes in the French E3n Cohort
نویسندگان
چکیده
Aims/hypothesis. Two US randomized trials found a lower incidence of type 2 diabetes among women treated by menopausal hormone therapy (MHT) with oral conjugated equine estrogen combined with medroxyprogesterone acetate. The purpose of this study was to evaluate the influence of various MHTs, according to their formulation and route of administration, on new-onset diabetes in a cohort of postmenopausal French women. 5
منابع مشابه
Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle G n rale de l Education
Aims/hypothesis Two US randomized trials found a lower incidence of type 2 diabetes among women treated by menopausal hormone therapy (MHT) with oral conjugated equine estrogen combined with medroxyprogesterone acetate. The purpose of this study was to evaluate the influence of various MHTs, according to their formulation and route of administration, on new-onset diabetes in a cohort of postmen...
متن کاملPostmenopausal hormone therapy and asthma onset in the E3N cohort.
BACKGROUND Epidemiological studies have suggested that female hormones might play a role in asthma and that menopausal hormone therapy (MHT or hormone replacement therapy (HRT)) might increase the risk of asthma in postmenopausal women. The only prospective study addressing this issue reports an increase in the risk of developing asthma which was similar for oestrogen alone and oestrogen/proges...
متن کاملRisk of osteoporotic fractures after discontinuation of menopausal hormone therapy: results from the E3N cohort.
While current use of menopausal hormone therapy (MHT) reduces the risk of osteoporotic fractures, epidemiologic studies suggest that protection wears off rapidly after discontinuation of treatment. The authors identified 5,589 first osteoporotic fractures (2,235 major osteoporotic fractures) among 70,182 postmenopausal women from the French E3N cohort (1992-2008) and used Cox multivariate propo...
متن کاملRisk factors for onset of menopausal symptoms: results from a large cohort study.
OBJECTIVES Menopause, the permanent cessation of ovarian activity, is part of normal aging, resulting in climacteric symptoms for most women, particularly in Western countries. The objective of the present study was to analyse risk factors for onset of menopausal symptoms. METHODS Analyses were based on the 28,118 women participating in the French E3N cohort study who reached menopause betwee...
متن کاملAnthropometry, breast cancer and menopausal status: use of repeated measurements over 10 years of follow-up-results of the French E3N women's cohort study.
The association between weight, BMI and breast cancer was analyzed on 94,805 women of the E3N cohort according to their menopausal status. Seven hundred eighty-six incident invasive premenopausal breast cancers and 1,522 incident invasive postmenopausal breast cancers occurred during a mean follow-up of 9.7 years. Weight and BMI were updated every 24 months and considered as time-dependent vari...
متن کامل