Helix-Loop-Helix PAS Protein NEPAS Hypoxia-Inducible Factor-Related Basic Remodeling in Mice Lacking the Abnormal Heart Development and Lung
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چکیده
Published Ahead of Print 10 December 2007. 10.1128/MCB.01332-07. 2008, 28(4):1285. DOI: Mol. Cell. Biol. Fujii-Kuriyama, Lorenz Poellinger and Masayuki Yamamoto Miyauchi, Katsutoshi Goto, Kinuko Ohneda, Yoshiaki Takashi Motoyuki Iemitsu, Yuichi Makino, Hirotoshi Tanaka, Toshiharu Yamashita, Osamu Ohneda, Masumi Nagano, Helix-Loop-Helix PAS Protein NEPAS Hypoxia-Inducible Factor-Related Basic Remodeling in Mice Lacking the Abnormal Heart Development and Lung
منابع مشابه
The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded.
The Drosophila melanogaster (Dm) similar (sima) gene was isolated using a low-stringency hybridization screen employing a Dm single-minded gene basic helix-loop-helix (bHLH) DNA probe. sima is a member of the bHLH-PAS gene family and the conceptual protein shares a number of structural features, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches. Sima is most closely re...
متن کاملStructural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Biological responses to oxygen availability play important roles in development, physiological homeostasis, and many disease processes. In mammalian cells, this adaptation is mediated in part by a conserved pathway centered on the hypoxia-inducible factor (HIF). HIF is a heterodimeric protein complex composed of two members of the basic helix-loop-helix Per-ARNT-Sim (PAS) (ARNT, aryl hydrocarbo...
متن کاملCardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha.
OBJECTIVES Previous studies have revealed the essential role of hypoxia-inducible factor-1alpha (HIF-1alpha), a basic helix-loop-helix transcription factor, in cardiovascular development. We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-)). METHODS We analyzed cardiovas...
متن کاملExpression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of the Ah receptor (AHR) and hypoxia inducible factor 1a (HIF1a). These dimers mediate biological responses to xenobiotic exposure and low oxygen tension. The recent cloning of ARNT and HIF1 homologues (ARNT2 and HIF2a) indicates that at least six distinct bHLH-PAS heterodimeric combinations can occur in response to a n...
متن کاملSequence Analysis and Phylogenetic Studies of Hypoxia-Inducible Factor-1α
Hypoxia-inducible factors (HIF) belong to the basic helix loop helix-PER ARNT SIM (bHLH-PAS) family of transcription factors that induce metabolic reprogramming under hypoxic condition. The phylogenetic studies of hypoxia-inducible factor-1α (HIF-1α) sequences across different organisms/species may leave a clue on the evolutionary relationships and its probable correlation to tumorigenesis and ...
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