Systems biology of Streptococcus mutans for drug development
نویسنده
چکیده
Streptococcus mutans is a human pathogen highly adapted to the oral cavity and a key component of dental plaque. It has an important role in polymicrobial biofilm diseases like caries, periodontitis and endocarditis, all of which are correlated with systemic non-communicable diseases (arthritis, cardiovascular disease). S. mutans forms strong biofilms, is tolerant to low pH, and has a sophisticated quorum sensing system for interspecies and intraspecies communication. An exceptionally high rate of horizontal gene transfer is reflected in its genome architecture and the open pan genome of this species [1,2].
منابع مشابه
Investigating the antibacterial effects of some Lactobacillus, Bifidobacterium and acetobacter strains killed by different methods on Streptococcus mutans and Escherichia coli
Although there are many health advantages assigned to different live bacteria such as probiotics, some health threatening effects have also been reported. For example, live bacteria can transfer antibiotic resistance genes to other commensal and opportunistic bacteria of gastrointestinal tract. Recently, it was shown that using killed bacteria have some advantages over live ones. In this resear...
متن کاملThe Frequency of Streptococcus Mutans and Lactobacillus spp.in 3-5-year- old Children with and without Dental Caries
Abstract Background and Objective: The high occurrence of early childhood caries (ECC) is one of the most common problems in children dentistry. Streptococcus mutans and lactobacilli.spp are closely associated with the development of early childhood caries (ECC). Therefore, the aim of this study was to investigate the frequency of streptococcus mutans and lactobacilli.spp in 3-5 –year- old ch...
متن کاملGenome-wide essential gene identification in Streptococcus sanguinis
A clear perception of gene essentiality in bacterial pathogens is pivotal for identifying drug targets to combat emergence of new pathogens and antibiotic-resistant bacteria, for synthetic biology, and for understanding the origins of life. We have constructed a comprehensive set of deletion mutants and systematically identified a clearly defined set of essential genes for Streptococcus sanguin...
متن کاملSalivary Streptococcus mutans and Lactobacilli Levels as Indicators of Dental Caries Development in Iranian Patients with Systemic Sclerosis
Background and Objective: Systemic sclerosis is an autoimmune disorder with orofacial manifestations, including tooth decay. Lactobacilli can inhibit biofilm formation and growth of cariogenic pathogens, such as Streptococcus mutans. We aimed to assess the salivary levels of S. mutans and Lactobacilli as indicators of dental caries development in patients with systemic sclerosis. Methods: In t...
متن کاملDifferent Roles of EIIAB and EII in Regulation of Energy Metabolism, Biofilm Development, and Competence in Streptococcus mutans
Different Roles of EIIAB and EII in Regulation of Energy Metabolism, Biofilm Development, and Competence in Streptococcus mutans Jacqueline Abranches, Melissa M. Candella, Zezhang T. Wen, Henry V. Baker, and Robert A. Burne* Department of Oral Biology, University of Florida College of Dentistry, P.O. Box 100424, Gainesville, Florida 32610, and Department of Molecular Genetics and Microbiology, ...
متن کامل