Bioavailability of Ascorbic Acid in Camels (Camelus dromedarius) Following Administration by Different Routes
نویسندگان
چکیده
This study reports the bioavailability of ascorbic acid in four adult female camels following administration at a dose of 50 mg/kg intravenously (i.v.), subcutaneously (s.c.) or orally (p.o.). The halflife of elimination following i.v. Injection (178.3 min.) was longer than after s.c. (145.2 min) or p.o. administration (110.0 min) (P < 0.05). Following s.c. injection, the maximum concentration (Cmax) obtained (28.4 mcg/ml) was higher than that for p.o. (14.29 mcg/ml) (P < 0.01). However, the time to reach Cmax (Tmax) was shorter after p.o. (75.5 min) compared to the s.c. route (181.5 min) (P < 0.01). The bioavailability following s.c. injection was found to be much greater than after giving the drug orally. It can be concluded that, if ascorbic acid administration is justified in camels, the s.c. route is more suitable than the i.v. or the oral route.
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