Role of attP in integrase-mediated integration of the Shigella resistance locus pathogenicity island of Shigella flexneri.
نویسندگان
چکیده
The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.
منابع مشابه
Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 3 شماره
صفحات -
تاریخ انتشار 2004