Significance of Nucleolar Organizer Regions in Prostate Adenocarcinomas
نویسندگان
چکیده
The aim of this study was to define the relation between silver stained nucleolar organizer regions (AgNORs) count and histological grade, and clinical stage in needle biopsy specimens of 65 prostatic adenocarcinomas. Histological grade was determined according to the modified Gleason system. AgNORs were evaluated by the counting method on routine histological sections stained with silver. There was a significantly increase of AgNOR count in high versus low grade prostate carcinomas. AgNORs increased significantly with clinical stage. Mean AgNOR count was significantly higher in lymph node metastases than in primary tumours. These data demonstrate that AgNOR counts reflects the proliferative activity of prostate adenocarcinomas and could be useful as prognostic factor in prostatic needle biopsy specimens.
منابع مشابه
Fractal Analysis and the Diagnostic Usefulness of Silver Staining Nucleolar Organizer Regions in Prostate Adenocarcinoma
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