Epigenetic Alteration of Receptor Tyrosine Kinases in Cancer
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چکیده
In the process of cellular carcinogenesis, genetic and epigenetic mechanisms contribute to abnormal expression of genes. Conrad Waddington introduced the term ‘‘epigenetics’’ in 1942 (Goldberg, Allis et al. 2007) to describe heritable changes in gene expression that have no connection with changes in DNA sequence (Yoo and Jones 2006; Goldberg, Allis et al. 2007). The molecular basis of epigenetics is complex and involves DNA methylation, histone modifications, chromatin remodeling and microRNAs (Esteller 2006).
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تاریخ انتشار 2012