Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.
نویسندگان
چکیده
Changes in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy.
منابع مشابه
Retinal arteriolar narrowing predicts incidence of diabetes: the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study.
OBJECTIVE To examine the relationship of retinal vascular caliber to incident diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study recruited adults aged 25+ years across Australia in 1999-2000, with a follow-up 5 years later in 2004-2005. Participants' glycemic status was classified using fasting plasma glucose (FPG)...
متن کاملRetinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes
OBJECTIVE Alterations in retinal vascular caliber may reflect early subclinical microvascular dysfunction. In this study, we examined the association of retinal vascular caliber to incident retinopathy in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS This was a prospective cohort study of 645 initially retinopathy-free type 1 diabetic patients, aged 12-20 years. Participant...
متن کاملLongitudinal Association of Glucose Metabolism with Retinopathy: Results from the Australian Diabetes Obesity and Lifestyle study (AusDiab)
متن کامل
Longitudinal Association of Glucose Metabolism With Retinopathy
OBJECTIVE We determined the longitudinal association of glucose metabolism with retinopathy in a sample of the Australian population. RESEARCH DESIGN AND METHODS The Australian Diabetes Obesity and Lifestyle (AusDiab) study is a national, longitudinal study of adults aged > or =25 years from 42 randomly selected areas of Australia. Retinopathy was assessed at baseline in 1999-2000 and 5 years...
متن کاملCentre for Medical and Health Sciences Education
The proposed study will measure and characterize early retinal vessel changes in persons with diabetes and persons at high risk of diabetes (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], and the metabolic syndrome) in the Australian Diabetes, Obesity and Lifestyle Study (AusDiab), a population-based study of risk factors and complications of diabetes. Specifi c Aims of the s...
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ورودعنوان ژورنال:
- Diabetes care
دوره 31 4 شماره
صفحات -
تاریخ انتشار 2008