Permeation properties of the hair cell mechanotransducer channel provide insight into its 1 molecular structure
نویسندگان
چکیده
B. Pan1, J Waguespack3, M.E. Schnee1, C., LeBlanc3., A.J. Ricci1,2* 3 1 -Department of Otolaryngology, Stanford University, 300 Pasteur Dr. Stanford CA 94305 4 2-Department of Molecular and Cellular Physiology Stanford University, 300 Pasteur Dr. 5 Stanford CA 94305 6 3Neuroscience Centerat Louisiana State Health Sciences Center, 2020 Gravier St New Orleans 7 LA 70125 8 Corresponding author: Anthony Ricci PhD, Department of Otolaryngology, Stanford 9 University, 300 Pasteur Dr. Edwards Bldg. R145 Stanford CA 94305 Email: 10 [email protected] 11
منابع مشابه
Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.
Mechanoelectric transducer (MET) channels, located near stereocilia tips, are opened by deflecting the hair bundle of sensory hair cells. Defects in this process result in deafness. Despite this critical function, the molecular identity of MET channels remains a mystery. Inherent channel properties, particularly those associated with permeation, provide the backbone for the molecular identifica...
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Zebrafish lateral-line hair cells are an in vivo model for studying hair cell development, function, and ototoxicity. However, the molecular identification and properties of the mechanotransducer (MET) channel in hair cells are still controversial. In this study, a noninvasive electrophysiological method, the scanning ion-electrode technique (SIET), was applied for the first time to investigate...
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