MRI Acceptance Protocol for the Multicenter GO Glioblastoma Project

Introduction Quality control (QC) protocols are now routinely used on clinical Magnetic Resonance Imaging (MRI) devices. Most of the time, these QC procedures are manufacturer-specific, and then not useable for multicenter projects involving multiple MRI systems from different vendors on different sites. The aim of the work package 1 of the Grand Ouest Glioblastoma Project (GOGP) [1], a multicenter bio-clinical study, was to find new imaging parameters with non-invasive method to highlight the heterogeneity and margin of the multiform glioblastoma (Fig. 1) and to enhance the grading prognostic. These new imaging biomarkers have to be correlated to biological biomarkers extracted from biopsies by Neuronavigation. In this multicenter project, that included an identical MRI protocol realized on different MRI devices, the key-point was the initial acceptance of imaging devices and sequences. For this purpose and to allow quantitative patients data comparison [2], we have proposed a specific common protocol for quality assessment.