Intimal Hyperplasia and Expression of Transforming Growth Factor-ß1 in Intimal Hyperplasia and Expression of Transforming Growth Factor-1 in Saphenous Veins and Internal Mammary Arteries before Coronary Artery Surgery
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چکیده
Ann Thorac Surg Andreas Hannekum and Sylvia Stracke Reinhard Friedl, Jun Li, Bernd Schumacher, Hartmut Hanke, Johannes Waltenberger, Surgery Saphenous Veins and Internal Mammary Arteries Before Coronary Artery Intimal Hyperplasia and Expression of Transforming Growth Factor-ß1 in http://ats.ctsnetjournals.org/cgi/content/full/78/4/1312 located on the World Wide Web at: The online version of this article, along with updated information and services, is
منابع مشابه
The role of gene therapy for intimal hyperplasia of bypass grafts.
BACKGROUND Proliferation of the intima is an early lesion of saphenous vein graft disease. Early patency rates of radial artery grafts are acceptable, but little is known about their risk of intimal hyperplasia. METHODS AND RESULTS To develop a model of intimal hyperplasia, we incubated human saphenous veins, internal mammary arteries, and radial arteries (n=6, 8, and 10, respectively) in an ...
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Saphenous veins used as arterial grafts are exposed to arterial levels of oxygen partial pressure (pO2), which are much greater than what they experience in their native environment. The object of this study is to determine the impact of exposing human saphenous veins to arterial pO2. Saphenous veins and left internal mammary arteries from consenting patients undergoing coronary artery bypass g...
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Autologous saphenous veins are commonly used to circumvent occluded coronary arteries during coronary artery bypass grafting (CABG) procedures.1 Although these vessels provide an effective treatment for myocardial ischemic disease, they are susceptible to accelerated atherosclerosis and fail in 50% of cases within 10 years of surgery.2–4 Venous graft disease occurs via 3 temporally distinct pro...
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BACKGROUND More than 50% of aortocoronary saphenous vein grafts are occluded 10 years after surgery. Intimal hyperplasia is the initial critical step in the progression toward occlusion. Internal mammary veins, which are physiologically prone to less hydrostatic pressure, may undergo an accelerated progression to intimal hyperplasia and thus be suitable for investigation of the mechanisms of ao...
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OBJECTIVES The biological functions of transforming growth factor-β signaling that involves Smad proteins have not been previously investigated with respect to coronary artery bypass grafts. The aim of the present study was to observe the immunostaining of proteins that are related to this signaling pathway. METHODS Fifteen remnants of coronary artery bypass grafts, including nine saphenous v...
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