Fibroblastic Reticular Cells: Organization
نویسندگان
چکیده
منابع مشابه
Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.
The connective tissue of any organ in the body is generally referred to as stroma. This complex network is commonly composed of leukocytes, extracellular matrix components, mesenchymal cells, and a collection of nerves, blood, and lymphoid vessels. Once viewed primarily as a structural entity, stromal cells of mesenchymal origin are now being intensely examined for their ability to directly reg...
متن کاملSpatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix.
Naive T cells encounter antigen-presenting cells within the cortex of lymph nodes to initiate primary immune responses. Within this T cell cortex is the reticular network (RN)--a system of collagen fibers and extracellular matrix (ECM) wrapped by fibroblastic reticular cells (FRC). We have investigated the distribution of various molecules, including ECM proteins and proteoglycans, in the T cel...
متن کاملUltrastructural and morphometrical studies on the reticular framework and reticular fibers in the reticuloendothelial system of rats.
The reticular framework and reticular fibers in the thymus, cervical lymph node, spleen and bone marrow of Wistar rats were studied by transmission electron microscopy and morphometrical method. The reticular framework was usually observed in these organs as a common structure that consisted mainly of the slender cytoplasmic processes of the fibroblastic reticular cells interconnected with tigh...
متن کاملTopological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Here, we have used a graph theory-based systems biology approach to determine topological properties and robustness of the LN FRC network in mice. We ...
متن کاملMultifunctional Roles of Reticular Fibroblastic Cells: More Than Meets the Eye?
Fibroblastic reticular cells (FRCs) are stromal cells found in secondary lymphoid organ. Despite its structural function in the lymph nodes being well established, recent studies indicate that the FRCs also play a key role in immunological processes, associated with cell transit, immune response, and cells activation quality, and contribute to peripheral tolerance. To this end, we focus this re...
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