A Newly Emerged Swine-Origin Influenza A(H3N2) Variant Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation.

نویسندگان

  • Weiping Cao
  • Margarita Mishina
  • Priya Ranjan
  • Juan A De La Cruz
  • Jin Hyang Kim
  • Rebecca Garten
  • Amrita Kumar
  • Adolfo García-Sastre
  • Jacqueline M Katz
  • Shivaprakash Gangappa
  • Suryaprakash Sambhara
چکیده

We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 212 12  شماره 

صفحات  -

تاریخ انتشار 2015