ABSTRACTS – TALKS Proteins: From Model Colloids to Cataract Formation
نویسندگان
چکیده
BOOKLET & PROGRAM
منابع مشابه
Model for amorphous aggregation processes.
The amorphous aggregation of proteins is associated with many phenomena, ranging from the formation of protein wine haze to the development of cataract in the eye lens and the precipitation of recombinant proteins during their expression and purification. While much literature exists describing models for linear protein aggregation, such as amyloid fibril formation, there are few reports of mod...
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Loss of transparency of the lens is termed cataract which is one of the commonest causes of blindness throughout the world. This major health problem appears to be much commoner in many developing countries such as India and Pakistan, where it causes visual disability at a substantially earlier age and several hypotheses have been put forward to explain this higher prevalence in these areas. Re...
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Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this colloid-protein analogy we demonstrate that weak attractions between unlike proteins help to maintain lens transparency in an extremely sensi...
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