Assessment of serum Prostate specific antigen (PSA) level among Sudanese women with polycystic ovarian syndrome In Khartoum state

PCOS is one of the commonest endocrine disorders in women of reproductive age group, cause of androgen excess in women. Prostatic specific antigen (PSA) is the most specific prostatic tumor marker in men , PSA can no longer be tumor-specific marker for only prostatic tissue, PSA may new one diagnostic tool for PCOS. Aim of study to assess the level of PSA in Sudanese women with PCOS and determine the performance of PSA in diagnosis of PCOS. Methodology cross sectional study, Blood samples of 50 Sudanese infertile women with PCOS as case, 11 infertile without PCOS and 40 health fertile as control was analyzed for TPSA. They were significant difference between the means of total prostate specific antigen (TPSA) in PCOS case (N=50) (0.025±0.013ng/ml) than normal fertile control (N=40) (0.004±0.005ng/ml) (p-value 0.001), and infertile without PCOS (N=11) (0.013±0.005) (p-value 0.004). Very weak, insignificant, negative correlation of TPSA and AMH (r =-0.132, p =0.360), ROC curve for TPSA regarding fertile control was found to be 0.924(92.4%) AUC =0.924 and 0.790(79.0%) AUC =0.790 regarding infertile without PCOS. The serum levels of TPSA are increased in PCOS than control group. The accuracy of TPSA in predicting PCOS is good when regarding fertile (health)| control, but decrease with infertile without PCOS. The accuracy and consistency of TPSA weak when comparing to AMH, Very weak negative correlation between TPSA and AMH.