Title: Scraping through the Ice: Uncovering the Role of Trpm8 in Cold Transduction Running Title: Trpm8, a Cold Sensor
نویسندگان
چکیده
Title: Scraping through the ice: Uncovering the role of TRPM8 in cold transduction Running title: TRPM8, a cold sensor Authors: Daniel D. McCoy, Wendy M. Knowlton and David D. McKemy* Author Affiliations: Neurobiology, University of Southern California, Los Angeles, California 90089, USA *Corresponding author information: David D. McKemy 3641 Watt Way, HNB 228 University of Southern California Los Angeles, California 90089 Phone (213)821-5724, Fax (213)740-5687 [email protected] Articles in PresS. Am J Physiol Regul Integr Comp Physiol (March 16, 2011). doi:10.1152/ajpregu.00631.2010
منابع مشابه
Scraping through the ice: uncovering the role of TRPM8 in cold transduction.
The proper detection of environmental temperatures is essential for the optimal growth and survival of organisms of all shapes and phyla, yet only recently have the molecular mechanisms for temperature sensing been elucidated. The discovery of temperature-sensitive ion channels of the transient receptor potential (TRP) superfamily has been pivotal in explaining how temperatures are sensed in vi...
متن کاملTherapeutic Potential of TRPM8 Modulators
The perception of temperature is a key tenet of sensory physiology and is critical in not only acute responses to changes in our environment, but also fundamental in regulating homeostatic mechanisms like core body temperature [1]. The somatosensory system is able to detect subtle changes in ambient temperature due to the coordinated efforts of thermosensory neurons which express temperature-se...
متن کاملContribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.
Transient receptor potential melastatin 8 (TRPM8) is the best molecular candidate for innocuous cold detection by peripheral thermoreceptor terminals. To dissect out the contribution of this cold- and menthol-gated, nonselective cation channel to cold transduction, we identified BCTC [N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide] as a potent and full blocker of recomb...
متن کاملTRPM8 in the negative regulation of TNFα expression during cold stress
Transient Receptor Potential Melastatin-8 (TRPM8) reportedly plays a fundamental role in a variety of processes including cold sensation, thermoregulation, pain transduction and tumorigenesis. However, the role of TRPM8 in inflammation under cold conditions is not well known. Since cooling allows the convergence of primary injury and injury-induced inflammation, we hypothesized that the mechani...
متن کاملThe roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity
BACKGROUND The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRPM8. The role of TRPA1 as a primary cold sensor in vitro is controversial, although there is eviden...
متن کامل