Fenofibrate can increase serum creatinine levels in renal insufficiency.

Sir, Fenofibrate is widely used to treat hypertriglyceridemia. It acts by increasing the expression of the LPL gene, while decreasing expression of apo-C III (a powerful inhibitor of LPL activity). Recent studies have shown that fenofibrate may cause a moderate reversible increase in serum creatinine levels.1 It has not been clearly studied whether the increased creatinine levels reflect a fenofibrate induced alteration of renal function or whether fenofibrate interferes with tubular handling of creatinine. Moreover there is no Indian data on this aspect.