Marine Compound Xyloketal B Reduces Neonatal Hypoxic-Ischemic Brain Injury

نویسندگان

  • Ai-Jiao Xiao
  • Wenliang Chen
  • Baofeng Xu
  • Rui Liu
  • Ekaterina Turlova
  • Andrew Barszczyk
  • Christopher Lf Sun
  • Ling Liu
  • Marielle Deurloo
  • Guan-Lei Wang
  • Zhong-Ping Feng
  • Hong-Shuo Sun
چکیده

Neonatal hypoxic-ischemic encephalopathy causes neurodegeneration and brain injury, leading to sensorimotor dysfunction. Xyloketal B is a novel marine compound isolated from a mangrove fungus Xylaria species (no. 2508) with unique antioxidant effects. In this study, we investigated the effects and mechanism of xyloketal B on oxygen-glucose deprivation-induced neuronal cell death in mouse primary cortical culture and on hypoxic-ischemic brain injury in neonatal mice in vivo. We found that xyloketal B reduced anoxia-induced neuronal cell death in vitro, as well as infarct volume in neonatal hypoxic-ischemic brain injury model in vivo. Furthermore, xyloketal B improved functional behavioral recovery of the animals following hypoxic-ischemic insult. In addition, xyloketal B significantly decreased calcium entry, reduced the number of TUNEL-positive cells, reduced the levels of cleaved caspase-3 and Bax proteins, and increased the level of Bcl-2 protein after the hypoxic-ischemic injury. Our findings indicate that xyloketal B is effective in models of hypoxia-ischemia and thus has potential as a treatment for hypoxic-ischemic brain injury.

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عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2014