Tyrosine Phosphatase 1B NO Attenuates Insulin Signaling and Motility in Aortic Smooth Muscle Cells via Protein
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چکیده
Mediated Mechanism − Tyrosine Phosphatase 1B NO Attenuates Insulin Signaling and Motility in Aortic Smooth Muscle Cells via Protein Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000020550.65963.E9 2002;22:1086-1092; originally published online May 2, 2002; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/22/7/1086 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2002/07/15/22.7.1086.DC1.html Data Supplement (unedited) at:
منابع مشابه
NO attenuates insulin signaling and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B-mediated mechanism.
OBJECTIVE Hyperinsulinemia is a significant risk factor for the pathogenesis of vascular disease. Protein tyrosine phosphatase 1B (PTP1B) has been recognized as a modulator of insulin signaling in nonvascular cells, and we have recently reported that NO increases the activity of PTP1B in rat vascular smooth muscle cells. In the present study, we tested the hypothesis that NO attenuates insulin-...
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Cell motility is an important determinant of vascular disease. We examined mechanisms underlying the effect of nitric oxide (NO) on motility in cultured primary aortic smooth muscle cells from newborn rats. The NO donor S-nitroso- N-acetyl-penicillamine (SNAP) increased the activity of protein tyrosine phosphatase 1B (PTP-1B). This effect was mimicked by a cGMP analog and blocked by the guanyl ...
متن کاملEssential role of protein kinase G and decreased cytoplasmic Ca levels in NO-induced inhibition of rat aortic smooth muscle cell motility
Zhuang, Daming, Alice-Corina Ceacareanu, Bogdan Ceacareanu, and Aviv Hassid. Essential role of protein kinase G and decreased cytoplasmic Ca levels in NO-induced inhibition of rat aortic smooth muscle cell motility. Am J Physiol Heart Circ Physiol 288: H1859–H1866, 2005. First published December 2, 2004; doi: 10.1152/ajpheart.01031.2004.—Hyperinsulinemia is a major risk factor for the developme...
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Hassid, Aviv, Shile Huang, and Jian Yao. Role of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H192–H198, 1999.—Recent studies have focused attention on the role of protein tyrosine kinases in vascular smooth muscle cell biology, but similar information regarding protein tyrosine phosphatases ...
متن کاملRole of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins.
Recent studies have focused attention on the role of protein tyrosine kinases in vascular smooth muscle cell biology, but similar information regarding protein tyrosine phosphatases (PTP) is sparse. PTP-1B is a ubiquitous nonreceptor phosphatase with uncertain function and substrates that are mostly unidentified. We used antisense oligodeoxynucleotides (ODN) against PTP-1B to investigate the ro...
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