Pharmacokinetics of liposomal amphotericin B in pleural fluid.
نویسندگان
چکیده
We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC(pleural fluid)) to that in serum (AUC(serum)) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 microg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.
منابع مشابه
Toxicity, stability and pharmacokinetics of amphotericin B in immunomodulator tuftsin-bearing liposomes in a murine model.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 4 شماره
صفحات -
تاریخ انتشار 2010