Further evidence for the role of nitric oxide in the antiarrhythmic effect of ischaemic preconditioning: The effect of peroxynitrite and changes in NOS- dependent NO production PhD Thesis

FURTHER EVIDENCE FOR THE ROLE OF NITRIC OXIDE IN THE ANTIARRHYTHMIC EFFECTS OF ISCHAEMIC PRECONDITIONING: THE EFFECT OF PEROXYNITRITE AND CHANGES IN NOS-DEPENDENT NO PRODUCTION Summary of PhD Thesis

Role of Nitric Oxide in the Antipruritic Effect of WIN 55,212-2, a Cannabinoid Agonist

Introduction: For centuries, cannabinoids are known to be effective in pain relief. Itch is an unpleasant sensation that provokes a desire to scratch. Since itch and pain are two sensations sharing a lot in common, we aimed to investigate whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behavior and also observe whether modulation of nitric oxide (NO) production...

O-8: Study of Peroxynitrite Levels, Arginase Activity and NO Synthase Activity in Seminal Plasma of Iraqi Leukocytospermic Patients

Background Leukocytes linked directly and indirectly to reactive oxygen species (ROS) formation. Although leukocytospermia is defined as the presence of ≥1×106 white blood cells/mL (WBC/mL) in a semen sample, the presence of less than 1×106 WBC/mL (low-level leukocytospermia) still can produce a detectable amount of ROS, impairing sperm function and lowering the chances of pregnancy. Low concen...

Assessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats

Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...

Nitric oxide and the bioactivities

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...