Microwave Assisted Synthesis, Molecular Docking and HIV-1 gp120 – CD4 Binding Inhibition Studies of Symmetrical N, N'-disubstituted Urea/Thiourea
نویسندگان
چکیده
An effective and eco friendly procedure under microwave irradiation, for synthesis of symmetrical disubstituted alkyl and aryl ureas from amine hydrochlorides using water as solvent medium has been developed. Based on molecular docking studies on HIV-1 gp120, synthesized compounds were evaluated for HIV-1 gp120 – CD4 binding inhibition and these molecules showed micro molar range (0.047 μM to 4.07 μM) of inhibition.
منابع مشابه
An Efficient One Pot Procedure for Preparation of Symmetrical N,N'-Disubstituted Urea from Aromatic and Aliphatic Amines and Urea under Microwave Irradiation
A phosgene-free synthesis of symmetrical N,N'-disubstituted urea by the reaction of aromatic and aliphatic primary amines and urea promoted by microwave irradiation in the presence of a suitable energy-transfer solvent such as N-N-dimethylacetamide is described.
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