GABAergic Excitation of Vasopressin Neurons: A Possible Mechanism Underlying Sodium-Dependent Hypertension
نویسندگان
چکیده
Department of Physiology, Korea University College of Medicine, Seoul 136-705, Republic of Korea; Neuroscience Research Institute, Korea University College of Medicine; Department of Physiology, Biomedical Science Institute and Brain Korea 21 Project Center, Kyung Hee University School of Medicine, Seoul 130-701, Republic of Korea, and; Department of Psychiatry & Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, CA 90024, USA.
منابع مشابه
GABAergic excitation of vasopressin neurons: possible mechanism underlying sodium-dependent hypertension.
RATIONALE Increased arginine-vasopressin (AVP) secretion is a key physiological response to hyperosmotic stress and may be part of the mechanism by which high-salt diets induce or exacerbate hypertension. OBJECTIVE Using deoxycorticosterone acetate-salt hypertension model rats, we sought to test the hypothesis that changes in GABA(A) receptor-mediated inhibition in AVP-secreting magnocellular...
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Yao Y, Fu L-Y, Zhang X, van den Pol AN. Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons. Am J Physiol Regul Integr Comp Physiol 302: R815–R824, 2012. First published January 18, 2012; doi:10.1152/ajpregu.00452.2011.—Neurons that synthesize melanin-concentrating hormone (MCH) colocalize GABA, regulate energy homeostasis, modulate water intake, and inf...
متن کاملVasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons.
Neurons that synthesize melanin-concentrating hormone (MCH) colocalize GABA, regulate energy homeostasis, modulate water intake, and influence anxiety, stress, and social interaction. Similarly, vasopressin and oxytocin can influence the same behaviors and states, suggesting that these neuropeptides may exert part of their effect by modulating MCH neurons. Using whole cell recording in MCH-gree...
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To study modulatory actions of nitric oxide (NO) on GABAergic synaptic activity in hypothalamic magnocellular neurons in the supraoptic nucleus (SON), in vitro and in vivo electrophysiological recordings were obtained from identified oxytocin and vasopressin neurons. Whole cell patch-clamp recordings were obtained in vitro from immunochemically identified oxytocin and vasopressin neurons. GABAe...
متن کاملChronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat.
In mammals, the increased secretion of arginine-vasopressin (AVP) (antidiuretic hormone) and oxytocin (natriuretic hormone) is a key physiological response to hyperosmotic stress. In this study, we examined whether chronic hyperosmotic stress weakens GABA(A) receptor-mediated synaptic inhibition in rat hypothalamic magnocellular neurosecretory cells (MNCs) secreting these hormones. Gramicidin-p...
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