Generation of ketenes from acid chlorides using NaH/crown ether shuttle-deprotonation for use in asymmetric catalysis.

نویسندگان

  • Andrew E Taggi
  • Harald Wack
  • Ahmed M Hafez
  • Stefan France
  • Thomas Lectka
چکیده

[reaction: see text] We describe methodology for the in situ generation of reactive monosubstituted ketenes from acid chlorides through a shuttle deprotonation process using NaH as an inexpensive stoichiometric base and a crown ether cocatalyst. We have successfully applied this new procedure to the catalytic, asymmetric synthesis of beta-lactams and alpha-haloesters.

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عنوان ژورنال:
  • Organic letters

دوره 4 4  شماره 

صفحات  -

تاریخ انتشار 2002