Cancer risk among residents of Rhineland-Palatinate winegrowing communities: a cancer-registry based ecological study

نویسندگان

  • Andreas Seidler
  • Gaël Paul Hammer
  • Gabriele Husmann
  • Jochem König
  • Anne Krtschil
  • Irene Schmidtmann
  • Maria Blettner
چکیده

AIM To investigate the cancer risk among residents of Rhineland-Palatinate winegrowing communities in an ecological study. METHODS On the basis of the Rhineland-Palatinate cancer-registry, we calculated age-adjusted incidence rate ratios for communities with a medium area under wine cultivation (>5 to 20 percent) and a large area under wine cultivation (>20 percent) in comparison with communities with a small area under wine cultivation (>0 to 5 percent). In a side analysis, standardized cancer incidence ratios (SIR) were computed separately for winegrowing communities with small, medium and large area under wine cultivation using estimated German incidence rates as reference. RESULTS A statistically significant positive association with the extent of viniculture can be observed for non-melanoma skin cancer in both males and females, and additionally for prostate cancer, bladder cancer, and non-Hodgkin lymphoma in males, but not in females. Lung cancer risk is significantly reduced in communities with a large area under cultivation. In the side-analysis, elevated SIR for endocrine-related tumors of the breast, testis, prostate, and endometrium were observed. CONCLUSION This study points to a potentially increased risk of skin cancer, bladder cancer, and endocrine-mediated tumors in Rhineland-Palatinate winegrowing communities. However, due to the explorative ecologic study design and the problem of multiple testing, these findings are not conclusve for a causal relationship.

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عنوان ژورنال:
  • Journal of Occupational Medicine and Toxicology (London, England)

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2008