Neutrophil Myeloperoxidase Measurement Uncovers Masked Megaloblastic Anemia
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چکیده
W e report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXl is rapidly measured as part of an automated complete blood count (Technicon H.1, Technicon Instruments Corp, Tarrytown NY). W e describe the range of MPXl levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean cell volume (MCV) and five without macrocytosis. Regardless of the MCV, our megaloblastic patients had
منابع مشابه
Neutrophil myeloperoxidase measurement uncovers masked megaloblastic anemia.
We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean c...
متن کاملRole of myeloperoxidase index in differentiation of megaloblastic and aplastic anemia.
BACKGROUND Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis. AIMS To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia. SETTINGS AND DESIGN The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations...
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Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic ...
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He also observed that the increase in MPO preceded the development of macrocytosis in megaloblastic anemia, thus suggesting that the threshold for the development of macrocytosis is higher than that for the development of increased MPO activity. We studied neutrophil MPO activity using the method of Herzog and Fahimi' and neutrophil MPO scoring by the method of Kaplow'in 40 chronic smokers (blo...
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Neutrophil hypersegmentation is an expected peripheral blood smear finding in megaloblastic anemias. But some clinical reports suggest that neutrophil hypersegmentation may also occur in patients with iron deficiency anemia. In this study we searched the presence of neutrophil hypersegmentation and thrombocytosis in patients with iron deficiency anemia but who had normal serum vitamin B12 and f...
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