Suppressed inflammatory gene expression during human hypertrophic scar compared to normotrophic scar formation.

Tissue engineered human scar models identify extracellular matrix and in!ammatory cytokine di"erences between normotrophic, hypertrophic and keloid scars

Hypertrophic and keloid scars are the result of unknown abnormalities in the wound healing process. The aim of this study was to develop physiologically relevant, human in vitro abnormal scar models for hypertrophic and keloid scars and compare these to normotrophic scars and normal skin to identify dierences in the pathogenesis of different scars. Keratinocytes and broblasts from normal skin a...

Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective

Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major challenge to scientists and physicians is to prevent adverse scar formation after severe trauma (e.g. burn injury) and understand why some individuals will form adverse scars even after relatively minor injury. Curren...

Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans.

Previous research suggests that in hypertrophic scars (HSs), an excess of microvessels is present compared with normotrophic scars (NSs). The aim of our study was to quantify vascular densities in HSs and normotrophic scars and to provide an insight into the kinetics of changes in the expression of angiogenic factors in time during wound healing and HS formation. Human presternal wound healing ...

Macrophage Influx and Phenotype during Normotrophic and Hypertrophic Scar Formation in Humans

Minimal extracorporeal circulation (MECC) does not result in less hypertrophic scar formation as compared to conventional extracorporeal circulation (CECC) with dexamethasone.

INTRODUCTION Cardiopulmonary bypass surgery is associated with a systemic inflammatory response through the interaction of air, blood and synthetic components in the bypass system and the physical trauma of surgery. An alternative cardiopulmonary bypass system, minimal extracorporeal circulation (MECC), has shown promising results in terms of reducing the inflammatory response. We hypothesized ...