1a. BAYESIAN MODELING OF ChIP-Seq DATA FOR DETECTING CHROMATIN REGIONS ATTACHED TO THE NUCLEAR ENVELOPE BASED ON LAMIN
نویسنده
چکیده
n = Student Award Winner | * = Presenter n = Student Award Winner | * = Presenter 1 20 12 S P R IN G M E E T IN G A P R IL 1 –4 Hyatt Regency Washington on Capitol Hill – Washington, DC WITH IMS AND SECTIONS OF ASA Abstracts
منابع مشابه
Identification of lamin B–regulated chromatin regions based on chromatin landscapes
Lamins, the major structural components of the nuclear lamina (NL) found beneath the nuclear envelope, are known to interact with most of the nuclear peripheral chromatin in metazoan cells. Although NL-chromatin associations correlate with a repressive chromatin state, the role of lamins in tethering chromatin to NL and how such tether influences gene expression have remained challenging to dec...
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Nuclear envelopes of somatic cells have at least two different major proteins in the 60-70(X 10(3] molecular weight range (lamins A(C) and B) that seem to be involved in chromatin attachment. In contrast, nuclear envelopes from clam germinal vesicles have only a single major protein of the same size class (approximately 67 X 10(3) Mr) and have no chromatin attached to them. The data presented i...
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Nuclear lamins contact the genome at the nuclear periphery through large domains and are involved in chromatin organization. Among broad peak calling algorithms available to date, none are suited for mapping lamin-genome interactions genome wide. We disclose a novel algorithm, enriched domain detector (EDD), for analysis of broad enrichment domains from chromatin immunoprecipitation (ChIP)-seq ...
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The A-type and B-type lamins form a filamentous meshwork underneath the inner nuclear membrane called the nuclear lamina, which is an important component of nuclear architecture in metazoan cells. The lamina interacts with large, mostly repressive chromatin domains at the nuclear periphery. In addition, genome-lamina interactions also involve dynamic association of lamin A/C with gene promoters...
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