Chronic hyperleptinemia results in the development of hypertension in pregnant rats 1 2 3 4
نویسندگان
چکیده
Chronic hyperleptinemia results in the development of hypertension in pregnant rats 1 2 3 4 Ana C. Palei, Frank T. Spradley and Joey P. Granger 5 6 Department of Physiology and Biophysics and Cardiovascular-Renal Research Center, 7 University of Mississippi Medical Center – 2500 North State Street, Jackson/MS, 39216 8 9 10 11 Running head: Hyperleptinemia increases blood pressure in pregnant rats 12 13 14 Address correspondence to: 15 Joey P. Granger, Ph.D. 16 Professor 17 Department of Physiology and Biophysics 18 University of Mississippi Medical Center 19 2500 North State Street 20 Jackson/MS 39216 21 Phone: (601) 815-1426 22 Fax: (601) 984-1833 23 Email: [email protected] 24 25
منابع مشابه
Chronic hyperleptinemia results in the development of hypertension in pregnant rats.
Despite the fact that obesity is a major risk factor for preeclampsia (PE), the pathophysiological mechanisms whereby obesity and metabolic factors such as leptin increase this risk are unclear. While human data have shown that hyperleptinemia is associated with PE, the long-term effect of hyperleptinemia on blood pressure during pregnancy is unknown. Thus we tested the hypothesis whether chron...
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BACKGROUND Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat. ...
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While soluble fms-like tyrosine kinase-1 (sFlt-1) and endothelin-1 (ET-1) have been implicated in the pathogenesis of preeclampsia (PE), the mechanisms whereby increased sFlt-1 leads to enhanced ET-1 production and hypertension remain unclear. It is well documented that nitric oxide (NO) production is reduced in PE; however, whether a reduction in NO synthesis plays a role in increasing ET-1 an...
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The prevalence of obesity among pregnant women is increasing. Evidence from human cohort studies and experimental animals suggests that offspring cardiovascular and metabolic function is compromised through early life exposure to maternal obesity. Previously, we reported that juvenile offspring of obese rats develop sympathetically mediated hypertension associated with neonatal hyperleptinemia....
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